Huayna Capac

Eleventh Sapa Inca, under whom the empire reached its greatest extent — pushing north into modern Ecuador and Colombia and founding a second capital at Quito. He died suddenly in Quito of an unidentified disease that swept through the imperial court — almost certainly smallpox, transmitted overland from the Spanish-introduced Caribbean epidemics years before any European set foot in Peru. His death without a designated heir triggered the dynastic civil war between his sons.