Spanish Conquest of Tenochtitlan

A two-year campaign by Hernán Cortés and roughly six hundred Spaniards, aided by smallpox and tens of thousands of indigenous allies who hated Mexica rule, destroyed the Aztec Empire. Moctezuma II received Cortés peacefully in Tenochtitlan in November 1519 and was held captive there; he died in disputed circumstances during the Mexica uprising of 1520. The eighty-day Spanish siege ended on 13 August 1521 with the capture of the last tlatoani, Cuauhtémoc.